This 50-minute lecture focuses on cell cycles—the research and results of experiments—including such topics as mitosis, cyclins, and protein synthesis. Rine begins by thanking students for emailing him questions about things that are not clear, so that he can bring them up. However, he points out that “The probability of me responding to email questions is inversely proportional to the length of the question. I get 300 emails a day.” He says that he finds it hard to respond to a question that asks, “Do we need to know x, y, z.” He points out that you don’t really need to know any of this to become a successful person. Then he goes on to say that it is important to know the context of experiments, the context is the story. He asks if everyone knows who wrote “Hamlet” and then shows a slide of Picasso’s Guernica, and explains the history of the painting, its context. “I assume you come with the facts in mind. The facts are in the book. I give you the story. You cannot learn biology without knowing the story.” That provides the context then for discussing several important experiments involving cell cycles. He approaches the whole lecture by talking about the researchers and their experiments, rather than just talking about what we know about cell cycles. He includes names and places, and some photos of the researchers. And he sets it up almost as a travelogue (“We’ll now go to Cambridge, English, to the lab of Tim Hunt, and to clams.” “We’ll now go to the exotic land of yeast genetics”). Of note: When students raise their hands, he says “Yes? What’s your name? And then repeats the student’s name as he answers the questions. He points out continually that this is almost like a mystery story, that it’s hard to follow and that students must stop him if they get lost. The board work (covering four double boards) is big, dramatic, and colorful. Rine’s tone throughout is excited, and he peppers his lecture with words and phrases such as “Isn’t this fantastic?” “This crazy activity…” “Boom!” and “If it quacks like a duck.” And he ends the lecture with a reminder of what the take-home message is. Rine works without notes.